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AssigneeThe Proctor & Gamble Company
InventorsRussell Phillip Elliott, Charles Winston Saunders, David John Weisgerber
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Leave-on personal care compositions comprising a stabilized enzyme, at least 30% water, less than 5% of an earth alkali metal salt, and an enzyme inhibitor having an inhibition constant (Kl) from 10 nanomolar (nM) to 25,000 nM. Also, a method of providing a skin care benefits, e.g. skin feel and/or skin appearance, preferably skin moisturization, skin softness, and/or skin smoothness, comprising topically applying a safe and effective amount of the inventive compositions described herein to skin in need of such a skin care benefit. Further, a method of providing a consumer with a leave-on enzyme-containing personal care product, wherein the enzyme is inhibited and inactive on shelf, but is active on skin without the need for a separate re-activation step, preferably wherein the leave-on enzyme-containing personal care product comprises a one of the inventive compositions described herein.
A leave-on composition for topical application in personal care, comprising (a) a stabilized enzyme, (b) at least about 30%, by weight of the composition, of water, (c) less than about 5%, by weight of the composition, of an earth alkali metal salt, and (d) an enzyme inhibitor having an inhibition constant (Ki) from about 10 nM to about 25,000 nM.
A composition according to claim 22 wherein said polyhydric alcohol is selected from the group consisting of xylitol, glycerine and polyethylene glycols having an average molecular weight of about 200 to about 400.
A leave-on composition for topical application in personal care, comprising (a) from about 0.001% to about 0.1%, by weight of the composition, of a subtilisin protease variant, (b) at least about 30%, by weight of the composition, of water, (c) less than about 0.05%, by weight of the composition, of an earth alkali metal salt, and (d) from about 0.005% to about 2%, by weight of the composition, of an enzyme inhibitor selected from the group consisting of (i) an enzyme inhibitor conjugate having the structure:
Dependencies are inferred from the claim text.