Antitumor agents
AssigneeHiroshi Maeda
InventorsHiroshi Maeda, Tomohiro Sawa, Takaaki Akaike
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Abstract
An antitumor agent, which is a combination of an oxidoreductase, such as xanthine oxidase chemically conjugated to a polymer such as poly ethylene glycol, for initial administration and accumulation in the tumor tissue followed by administration and of a substrate for the oxidoreductase which releases reactive oxygen species. Improved tumor selective cytotoxic activity results.
Claims7
(New) Antitumor agent comprising a combination of an oxidoreductase which is chemically conjugated with a polymer, and of a substrate of the oxidoreductase.
(New) A method for treating cancer, which comprises administering to a patient in need thereof a therapeutically effective amount of an oxidoreductase which is chemically conjugated with a polymer, and subsequently administering its substrate.
(New) A method of treating tumors comprising the steps of sequentially administering a first component A, D-amino acid oxidase, which is chemically conjugated with a polyethylene glycol, and thereafter,
- separately administering component B, D-amino acid, which is a substrate for the xanthine oxidase.
Dependencies are inferred from the claim text.