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OwnerJean-Louis Touraine, Kamel Sanhadji +2inventors
InventorsJean-Louis Touraine, Kamel Sanhadji, Pierre Leroy, Majid Mehtali
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A gene therapy composition of the present invention comprises one or more nucleotide fragments. The one or more nucleotide fragments taken together comprise at least (1) a nucleotide sequence (a) encoding human soluble CD4, (2) a nucleotide sequence (b) comprising at least nucleotide sequences encoding the heavy chain and the light chain of immunoglobulin IgG3, wherein the IgG3 is directed against at least one of the peptides selected from the group consisting of SEQ ID NO:2 to SEQ ID NO:26. The composition further comprises the nucleic elements required for replicating each of nucleotide sequences (a) and (b), in a host cell, when the host cell divides and for expressing under control each of nucleotide sequences (a) and (b) in the host cell.
A composition comprising one or more nucleotide fragments, wherein the one or more nucleotide fragments taken together comprise at least (1) an nucleotide sequence (a) encoding human soluble CD4, (2) an nucleotide sequence (b) comprising at least nucleotide sequences encoding the heavy chain and the light chain of immunoglobulin IgG3, said IgG3 being directed against at least one of the peptide selected from the group consisting of SEQ ID NO:2 to SEQ ID NO:26, and (3) the nucleic elements required for replicating each said nucleotide sequences (a) and (b), in a host cell, when said host cell divides and for expressing under control each of said nucleotide sequences (a) and (b) in said host cell.
A method for treating infectious disease, wherein at least (1) a first expression cassette comprising a nucleotide sequence (a) encoding human soluble CD4 and nucleic elements required for replicating nucleotide sequence (a) in a host cell, when said host cell divides, and for expressing under control said nucleotide sequence (a) in said host cell, (2) a second expression cassette comprising a nucleotide sequence (b) comprising at least nucleotide sequences encoding the heavy chain and the light chain of immunoglobulin IgG3, said IgG3 being directed against at least one of the peptide selected from the group consisting of SEQ ID NO:2 to SEQ ID NO:26, and nucleic elements required for replicating nucleotide sequence (b), when said host cell divides, and for expressing under control said nucleotide sequence (b) in said host cell,
A method for treating infectious disease, wherein at least (1) a first recombinant vector comprising a nucleotide sequence (a) encoding human soluble CD4 and nucleic elements required for replicating nucleotide sequence (a) in a host cell, when said host cell divides, and for expressing under control said nucleotide sequence (a) in said host cell, (2) a second recombinant vector comprising a nucleotide sequence (b) comprising at least nucleotide sequences encoding the heavy chain and the light chain of immunoglobulin IgG3, said IgG3 being directed against at least one of the peptide selected from the group consisting of SEQ ID NO:2 to SEQ ID NO:26, and nucleic elements required for replicating nucleotide sequence (b), when said host cell divides, and for expressing under control said nucleotide sequence (b) in said host cell,
The method of claim 36, wherein said infectious disease is caused by HIV-1 retrovirus.
Dependencies are inferred from the claim text.