Modified cytokines for use in cancer therapy
AssigneeFondazione Centro San Raffaele Del Monte Tabor
InventorAngelo Corti
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Abstract
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
Claims16
A conjugation product between a cytokine selected from TNF or IFNγ and a ligand of the CD13 receptor.
A conjugation product as claimed in any one of the preceding claims, wherein the cytokine is derivatized with polyethylene glycol or an acyl residue.
A conjugation product as claimed in any one of the preceding claims, wherein the cytokine is further conjugated with an antibody, or a fragment thereof, directed to a tumoral antigen, a tumoral angiogenic marker or a component of the extracellular matrix, or with biotin.
A cDNA encoding for a cytokine selected from TNF and IFNγ bearing a 5′ or 3′ contiguous sequence encoding a CD13 ligand.
Dependencies are inferred from the claim text.