Pharmaceutical aerosol formulation
AssigneeSmithKline Beecham Corporation
InventorsPascal Cavaillon, Nathalie Llorca, Olivier Louis, Patrick Rosier
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Abstract
The present invention relates to novel pharmaceutical aerosol formulations comprising: (A) a therapeutic agent in the form of particles coated by at least one coating excipient and at least one surfactant, in suspension in (B) a liquefied propellant gas for the administration of therapeutic agents particularly by the pulmonary route and to process for preparing these formulations. It also relates to novel particles suitable for use in such formulations.
Claims43
A pharmaceutical aerosol formulation, characterised in that it comprises:
- (A) a therapeutic agent in the form of particles coated by at least one coating excipient and at least one surfactant, in suspension in
- (B) a liquefied propellant gas.
Particles of pharmaceutical active principles obtainable by a process which comprises the stages which consist
- (a) in preparing a suspension containing
- the therapeutic agent in the form of particles,
- a suspending medium which is a non-solvent for the therapeutic agent,
- the coating excipient dissolved in the suspending medium and
- the surfactant;
- and
- (b) in spray drying the suspension of the active principle obtained in stage (a), so as to obtain drug particles coated by the excipient and by the surfactant.
Dependencies are inferred from the claim text.