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US 2003/0157031 A1Published application
Method of and apparatus for forming and administering fine particles
OwnerLalit Chordia, Poongunran Muthukumaran +1inventors
InventorsLalit Chordia, Poongunran Muthukumaran, Brian Moyer
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Abstract
Present invention provides a method and device for the formation of fine particles of a desired substance and for the immediate subsequent administration to an external environment like human or animal tissues. It also provides ways to control the output and solvent, antisolvent concentrations in the particles.
Claims28
A method of formation of a desired substance as fine particles and means of subsequent administration to an external environment comprising:
- a. Using the desired substance that is soluble in a solvent but has minimal solubility in an antisolvent.
- b. Using an antisolvent that is miscible with a solvent.
- c. Applying a dispersion having at least a solvent and the desired substance into a chamber.
- d. Applying an antisolvent at or near supercritical conditions to the applied dispersion.
- e. Using the pressure of the antisolvent to propel the particles of the desired substance to an external environment.
2 more elements
An apparatus for the administration of a desired substance following particle formation comprising:
- a. Using a desired substance, solvent and antisolvent, which is near or above the critical point, to form fine particles.
- b. Applying a dispersion having at least a solvent and the desired substance into a chamber.
- c. Applying an antisolvent at near or supercritical conditions to the applied dispersion.
- d. Using the pressure of the antisolvent inside the chamber to propel the desired substance to an external environment.
1 more element
Dependencies are inferred from the claim text.