Methods of administering and enhancing absorption of pharmaceutical agents
AssigneeGenerex Pharmaceuticals Incorporated
InventorPankaj Modi
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Abstract
Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for administering the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth, which has been demonstrated to achieve peak plasma levels of the pharmaceutical agent in about thirty minutes.
Claims30
A method of administering a pharmaceutical agent to the oral or pulmonary mucosae of a patient comprising:
- spraying a composition comprising said pharmaceutical agent to said oral or pulmonary mucosae with a metered dose dispenser,
- said pharmaceutical agent selected from the group consisting of insulin, heparin, low molecular weight heparin, hirulog, hirugen, huridine, interferons, cytokines, mono and polyclonal antibodies, immunoglobins, chemotherapeutic agents, vaccines, glycoproteins, bacterial toxoids, hormones, calcitonins, glucagon like peptides, antibiotics, thrombolytic compounds, platelet inhibitors, DNA, RNA, gene therapeutics, antisense oligonucleotides, hypnotics, and steroids, and
- said pharmaceutical agent is absorbed through said oral or pulmonary mucosae and a peak plasma level of said pharmaceutical agent is obtained in less than about 1 hour.
A method of enhancing absorption of a pharmaceutical agent administered to the oral or pulmonary mucosae of a patient comprising:
- spraying a composition comprising said pharmaceutical agent to said oral or pulmonary mucosae with a metered dose dispenser,
- said pharmaceutical agent selected from the group consisting of insulin, heparin, low molecular weight heparin, hirulog, hirugen, huridine, interferons, cytokines, mono and polyclonal antibodies, immunoglobins, chemotherapeutic agents, vaccines, glycoproteins, bacterial toxoids, hormones, calcitonins, glucagon like peptides, antibiotics, thrombolytic compounds, platelet inhibitors, DNA, RNA, gene therapeutics, antisense oligonucleotides, hypnotics and steroids, and
- said pharmaceutical agent is absorbed through said oral or pulmonary mucosae and a peak plasma level of said pharmaceutical agent is obtained in less than about 1 hour.
A method of administering a pharmaceutical agent to the oral mucosae of a patient comprising:
- spraying a composition comprising said pharmaceutical agent to said oral mucosae with a metered dose dispenser,
- said pharmaceutical agent selected from the group consisting of insulin, heparin, low molecular weight heparin, hirulog, hirugen, huridine, interferons, cytokines, mono and polyclonal antibodies, immunoglobins, chemotherapeutic agents, vaccines, glycoproteins, bacterial toxoids, hormones, calcitonins, glucagon like peptides, antibiotics, thrombolytic compounds, platelet inhibitors, DNA, RNA, gene therapeutics, antisense oligonucleotides, opioids, narcotics, hypnotics, steroids and pain killers,
- said pharmaceutical agent is absorbed through the oral mucosae and a peak plasma level of said pharmaceutical agent is obtained in less than about 1 hour.
A method of enhancing absorption of a pharmaceutical agent administered to the oral mucosae of a patient comprising:
- spraying a composition comprising said pharmaceutical agent to said oral mucosae with a metered dose dispenser,
- said pharmaceutical agent selected from the group consisting of insulin, heparin, low molecular weight heparin, hirulog, hirugen, huridine, interferons, cytokines, mono and polyclonal antibodies, immunoglobins, chemotherapeutic agents, vaccines, glycoproteins, bacterial toxoids, hormones, calcitonins, glucagon like peptides, antibiotics, thrombolytic compounds, platelet inhibitors, DNA, RNA, gene therapeutics, antisense oligonucleotides, opioids, narcotics, hypnotics, steroids and pain killers,
- said pharmaceutical agent is absorbed through the oral mucosae and a peak plasma level of said pharmaceutical agent is obtained in less than about 1 hour.
Dependencies are inferred from the claim text.