Methods and compositions for modulating carbohydrate metabolism
OwnerRobert V. Farese JR., Hubert C. Cheninventors
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Abstract
Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.
Claims31
A method of modulating sensitivity of a host to insulin and/or leptin, said method comprising:
- administering to said host an effective amount of one or more active agents that alter DGAT1 activity in said host to modulate sensitivity of said host to insulin and/or leptin.
A method of modulating carbohydrate metabolism in a host, said method comprising:
- administering to said host an effective amount of one or more active agents that modulate DGAT1 activity in said host and modulate carbohydrate metabolism in said host.
A method of treating a host suffering from a condition associated with abnormal carbohydrate metabolism, said method comprising:
- administering to said host an effective amount of one or more active agents that modulate DGAT activity in said host and treat said host for said condition.
A pharmaceutical preparation comprising a DGAT1 activity modulatory agent in a pharmaceutically acceptable vehicle.
A kit comprising:
- (a) a pharmaceutical preparation comprising at least one active DGAT1 modulatory agent;
- and
- (b) instructions for treating a host suffering from a condition associated with abnormal carbohydrate metabolism by administering to said host an effective amount of one or more active DGAT1 modulatory agents to treat said host for said condition.
Dependencies are inferred from the claim text.