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AssigneePolybiomed Limited
InventorsKadem Gayad Al-Lamee, Yousef Samih Taktak
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A composition which is photopolymerizable in the presence of water comprises: (a) a first monomer having olefinic unsaturation and a flexible hydrophillic chain and which may be polyethylene glycol ethyl ether methacrylate or methoxypolyethylene glycol methacrylate; (b) a second monomer having olefinic unsaturation, high free radical polymerization efficiency and which imparts tackiness on curing, and which may be N,N-dimethylacrylamide or 2-hydroxyethylacrylate; (c) a cross-linking agent; and (d) a photoinitiator. The composition may be formed into a thin layer containing 2-40 wt % of water before it is cured so that the product is a film. The cured film is transparent, adheres selectively to dry) skin, and can be used as a wound dressing. Where the second monomer provides conductivity-imparting groups it may also be used as an electrode (e.g. as a grounding plate). If desired, 2-20 wt % of a low molecular weight polyol e.g. propylene glycol may be added to increase the adhesiveness of the cured film and/or a water-soluble natural or synthetic polymer may be added to increase its adhesiveness, tackiness and improve the casting process.
A composition which is photopolymerizable in the presence of water comprising:
The composition of any preceding claim, wherein the average molecular weight of the first monomer is about 200-700.
The composition of any preceding claim, wherein the average molecular weight of the first monomer is about 300-600.
The composition of any preceding claim, wherein R8 is
The composition of any preceding claim wherein the cross-linking agent is of formula:
The composition of any preceding claim, wherein there are present 0.5-10 or more parts by weight of the second monomer per part by weight or the first monomer.
The composition of any preceding claim, further comprising water in an amount such that the composition on curing is a hydrogel.
The composition of any preceding claim, comprising 5-40 25 % water.
The composition of any preceding claim, wherein the low molecular weight polyol is selected from polyethylene glycol, propylene glycol, low molecular weight polyethylene glycols, low molecular weight polyethylene/polypropylene glycols and glycerol.
The composition of any preceding claim, further comprising a biologically active material.
A composition which is photopolymerizable in the presence of water comprising:
Use in the manufacture of a wound dressing of a hydrogel sheet material obtained by photopolymerizing in the presence of water and a photoinitiator:
Dependencies are inferred from the claim text.