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US 2003/0153951 A1Published application
Methods and devices for treating arrhythmias using defibrillation shocks
OwnerRaymond E. Ideker, Nipon Chattipakorninventors
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Abstract
The present invention includes both methods and apparatus for improving defibrillation. In particular, the present invention includes methods and devices for administering a calcium channel blocker and/or calmodulin kinase inhibitor that prevents afterdepolarizations and antiarrhythmic drugs to decrease the threshold shock from a therapeutic threshold shock.
Claims48
A method of decreasing the shock strength needed to treat an arrhythmia comprising:
- detecting an arrhythmia in the heart of a subject;
- administering a therapeutic electric shock to the heart of said subject to treat said arrhythmia;
- and
- administering a therapeutic drug selected from the group consisting of a calcium channel blocker, a calmodulin blocker, a calmodulin kinase inhibitor and an antiarrhythmic drug to said subject at a time and in an amount effective to decrease the strength of said shock required to treat said arrhythmia.
1 more element
A cardiac device for treating arrhythmia in a subject in need thereof, comprising:
- an arrhythmia detector configured to determine if a cardiac arrhythmia is occurring from electrical activity sensed from the heart of a subject;
- a controller operatively associated with said detector;
- an injector operatively associated with said controller to administer a therapeutic drug selected from the group consisting of calcium channel blocker, a calmodulin blocker, a calmodulin kinase inhibitor and an antiarrhythmic drug to said subject when a cardiac arrhythmia is detected;
- and
- a shock generator operatively associated with said controller and configured to deliver a therapeutic electric shock to the heart of said subject.
2 more elements
A cardiac device comprising:
- a sensing electrode positioned within a subject's heart configured to measure signals from said subject's heart;
- a power supply;
- a controller operatively associated with said sensing electrode;
- a plurality of electrodes operatively associated with said controller configured to deliver a therapeutic electric shock to said subject's heart;
- a catheter operatively associated with said controller configured to deliver a therapeutic amount of a therapeutic drug selected from the group consisting of calcium channel blocker, a calmodulin blocker, a calmodulin kinase inhibitor and an antiarrhythmic drug to said subject.
2 more elements
A method of decreasing the shock strength needed to treat an arrhythmia comprising:
- detecting an arrhythmia in the heart of a subject;
- administering a therapeutic electric shock to the heart of said subject to treat said arrhythmia;
- administering a therapeutic drug selected from the group consisting of a calcium channel blocker, a calmodulin blocker, a calmodulin kinase inhibitor and a first antiarrhythmic drug to said subject at a time and in an amount effective to decrease the strength of said shock required to treat delayed afterdepolarizations;
- and
- administering a second antiarrhythmic drug at a time and in an amount effective to prolong the refractory period.
2 more elements
A cardiac device for treating arrhythmia in a subject in need thereof, comprising:
- an arrhythmia detector configured to determine if a cardiac arrhythmia is occurring from electrical activity sensed from the heart of a subject;
- a controller operatively associated with said detector;
- an injector operatively associated with said controller to administer a therapeutic drug selected from the group consisting of calcium channel blocker, a calmodulin blocker, a calmodulin kinase inhibitor and a first antiarrhythmic drug to said subject when a cardiac arrhythmia is detected, wherein said injector operatively associated with said controller administers a second antiarrhythmic drug;
- and
- a shock generator operatively associated with said controller and configured to deliver a therapeutic electric shock to the heart of said subject.
2 more elements
A system for treating an arrhythmia comprising:
- a processor to detect a fibrillation event;
- a defibrillation source, wherein a therapeutic shock is administered after the processor detects the fibrillation event;
- a drug reservoir comprising a therapeutic drug selected from the group consisting of a calcium channel blocker, a colmodulin blocker and a calmodulin kinase inhibitor, wherein the therapeutic drug is administered proximate in time with the therapeutic shock and wherein the processor is configured to determine the amount of the therapeutic drug to be administered and the level of shock to be produced.
A cardiac device for treating an arrhythmia in a subject in need thereof, comprising:
- an arrhythmia detector configured to determine if the subject is likely to experience an arrhythmia;
- a controller operatively associated with said detector;
- an injector operatively associated with said controller to administer a therapeutic drug, said therapeutic drug selected from the group consisting of calcium channel blocker, a calmodulin blocker, a calmodulin kinase inhibitor and an antiarrhythmic drug to said subject.
Dependencies are inferred from the claim text.