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OwnerTatsuo Kumazaki, Satoru Muratainventors
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An intra pelvic cancer therapeutic agent perfusion apparatus and method for administering a cancer therapeutic agent to and recovering same from a cancer tissue site within the pelvis. The tip of a first sheath is percutaneously inserted into the femoral artery and the tip of a second sheath is inserted into the femoral vein. A first balloon catheter is inserted into the aorta through the femoral artery and a second balloon catheter is inserted into the vena cava through the femoral vein. The first balloon catheter is used to block the blood flow and the second balloon is inflated to form an intravenous closed region between the site of insertion in the vena cava and a lower limb side venous site. A body fluid containing a cancer therapeutic agent is administered to the intra arterial closed region through the first sheath and is removed therefrom through the second sheath.
An intrapelvic cancer therapeutic agent perfusion therapy, which is a cancer therapeutic agent perfusion therapy consisting in administering a cancer therapeutic agent to and recovering the same from a cancer tissue site occurring within the pelvis, characterized in that it comprises the step of percutaneously inserting the tip of a first sheath, which is a tubular body, into the femoral artery and causing the sheath to indwell therein, the step of percutaneously inserting the tip of a second sheath, which is a tubular body, into the femoral vein and causing the sheath to indwell therein, the step of percutaneously inserting a first balloon catheter having an inflatable first balloon at the tip of a flexible tubular body into the aorta through the femoral artery and causing the first balloon to indwell at a predetermined site of the aorta, the step of percutaneously inserting a second balloon catheter having an inflatable second balloon at the tip of a flexible tubular body into the vena cava through the femoral vein and causing the second balloon to indwell at a predetermined site of the cava, the step of blocking the blood flow at a lower limb side arterial site lower than the above predetermined site of the aorta, the step of blocking the blood flow at a lower limb side venous site lower than the above predetermined site of the cava, the step of inflating the first balloon to thereby form an intraarterial closed region between the above predetermined site of the aorta and the above lower limb side arterial site, the step of inflating the second balloon to thereby form an intravenous closed region between the above predetermined site of the cava and the above lower limb side venous site, the step of administering a body fluid containing a cancer therapeutic agent to the intraarterial closed region from the above first sheath, and the step of recovering a larger amount, as compared with the body fluid containing the above cancer therapeutic agent as fed, of a body fluid containing the cancer therapeutic agent from the above intravenous closed region through the second sheath.
An intrapelvic cancer therapeutic agent perfusion therapy, which is a cancer therapeutic agent perfusion therapy consisting in administering a cancer therapeutic agent to and recovering the same from a cancer tissue site occurring within the pelvis, characterized in that it comprises the step of percutaneously inserting a first balloon catheter having a first inflatable balloon at the tip of a flexible tubular body and a first hollow tubular part connecting the rear end portion of the above tubular body with the tip portion thereof, into the aorta through the femoral artery and causing the first balloon to indwell in the aorta at a predetermined site, the step of causing a second balloon catheter having a second inflatable balloon at the tip of a flexible tubular body and a second hollow tubular part connecting the rear end portion of the above tubular body with the tip portion thereof, to indwell in the vena cava at a predetermined site, the step of blocking the blood flow at a lower limb side arterial site lower than the above predetermined site of the aorta, the step of blocking the blood flow at a lower limb side venous site lower than the above predetermined site of the cava, the step of inflating the first balloon to thereby form an intraarterial closed region between the above predetermined site of the aorta and the above lower limb side arterial site, the step of inflating the second balloon to thereby form an intravenous closed region between the above predetermined site of the cava and the above lower limb side venous site, the step of administering a body fluid containing a cancer therapeutic agent to the intraarterial closed region from the above first hollow tubular part, and the step of recovering a larger amount, as compared with the body fluid containing the above cancer therapeutic agent as fed, of a body fluid containing the cancer therapeutic agent from the above intravenous closed region through the second hollow tubular part.
An intrapelvic cancer therapeutic agent perfusion therapy, which is a cancer therapeutic agent perfusion therapy consisting in administering a cancer therapeutic agent to and recovering the same from a cancer tissue site occurring within the pelvis, characterized in that it comprises the step of percutaneously inserting the tip of a first sheath, which is a tubular body, into the femoral artery and causing the sheath to indwell therein, the step of percutaneously inserting the tip of a second sheath, which is a tubular body, into the femoral vein and causing the sheath to indwell therein, the step of percutaneously inserting a first balloon catheter having an inflatable first balloon at the tip of a flexible tubular body into the aorta through the femoral artery and causing the first balloon to indwell at a predetermined site of the aorta, the step of percutaneously inserting a second balloon catheter having an inflatable second balloon at the tip of a flexible tubular body into the vena cava through the femoral vein and causing the second balloon to indwell at a predetermined site of the cava, the step of blocking the blood flow at a lower limb side arterial site lower than the above predetermined site of the aorta, the step of blocking the blood flow at a lower limb side venous site lower than the above predetermined site of the cava, the step of inflating the first balloon to thereby form an intraarterial closed region between the above predetermined site of the aorta and the above lower limb side arterial site, the step of inflating the second balloon to thereby form an intravenous closed region between the above predetermined site of the cava and the above lower limb side venous site, the step of administering a body fluid containing a cancer therapeutic agent to the intraarterial closed region from the above first sheath, and the step of recovering a body fluid containing the cancer therapeutic agent from the above intravenous closed region through the second sheath, the step of subjecting the body fluid recovered in the body fluid recovering step to blood cleaning treatment comprising at least one of hemodialysis, hemofiltration, hemoabsorption and centrifugation and sending the thus-treated body fluid back into the body.
An intrapelvic cancer therapeutic agent perfusion therapy, which is a cancer therapeutic agent perfusion therapy consisting in administering a cancer therapeutic agent to and recovering the same from a cancer tissue site occurring within the pelvis, characterized in that it comprises the step of percutaneously inserting a first balloon catheter having a first inflatable balloon at the tip of a flexible tubular body and a first hollow tubular part connecting the rear end portion of the above tubular body with the tip portion thereof, into the aorta through the femoral artery and causing the first balloon to indwell in the aorta at a predetermined site, the step of causing a second balloon catheter having a second inflatable balloon at the tip of a flexible tubular body and a second hollow tubular part connecting the rear end portion of the above tubular body with the tip portion thereof, to indwell in the vena cava at a predetermined site, the step of blocking the blood flow at a lower limb side arterial site lower than the above predetermined site of the aorta, the step of blocking the blood flow at a lower limb side venous site lower than the above predetermined site of the cava, the step of inflating the first balloon to thereby form an intraarterial closed region between the above predetermined site of the aorta and the above lower limb side arterial site, the step of inflating the second balloon to thereby form an intravenous closed region between the above predetermined site of the cava and the above lower limb side venous site, the step of administering a body fluid containing a cancer therapeutic agent to the intraarterial closed region from the above first hollow tubular part, and the step of recovering a body fluid containing the cancer therapeutic agent from the above intravenous closed region through the second hollow tubular part, the step of subjecting the body fluid recovered in the body fluid recovering step to blood cleaning treatment comprising at least one of hemodialysis, hemofiltration, hemoabsorption and centrifugation and sending the thus-treated body fluid back into the body.
An intrapelvic cancer therapeutic agent perfusion therapy, which is a cancer therapeutic agent perfusion therapy consisting in administering a cancer therapeutic agent to and recovering the same from a cancer tissue site occurring within the pelvis, characterized in that it comprises the step of percutaneously inserting the tip of a first sheath, which is a tubular body, into the femoral artery and causing the sheath to indwell therein, the step of percutaneously inserting the tip of a second sheath, which is a tubular body, into the femoral vein and causing the sheath to indwell therein, the step of percutaneously inserting a first balloon catheter having an inflatable first balloon at the tip of a flexible tubular body into the aorta through the femoral artery and causing the first balloon to indwell at a predetermined site of the aorta, the step of percutaneously inserting a second balloon catheter having an inflatable second balloon at the tip of a flexible tubular body into the vena cava through the femoral vein and causing the second balloon to indwell at a predetermined site of the cava, the step of blocking the blood flow at a lower limb side arterial site lower than the above predetermined site of the aorta, the step of blocking the blood flow at a lower limb side venous site lower than the above predetermined site of the cava, the step of inflating the first balloon to thereby form an intraarterial closed region between the above predetermined site of the aorta and the above lower limb side arterial site, the step of inflating the second balloon to thereby form an intravenous closed region between the above predetermined site of the cava and the above lower limb side venous site, the step of administering a body fluid containing a cancer therapeutic agent to the intraarterial closed region from the above first sheath, and the step of recovering a body fluid containing the cancer therapeutic agent from the above intravenous closed region through the second sheath, and the above cancer therapeutic agent is at least one agent chosen from the group of an anticancer agent, a radioisotope, a gene for gene therapy, a DNA molecule for gene therapy, RNA molecule for gene therapy and a cell for gene therapy.
An intrapelvic cancer therapeutic agent perfusion therapy, which is a cancer therapeutic agent perfusion therapy consisting in administering a cancer therapeutic agent to and recovering the same from a cancer tissue site occurring within the pelvis, characterized in that it comprises the step of percutaneously inserting a first balloon catheter having a first inflatable balloon at the tip of a flexible tubular body and a first hollow tubular part connecting the rear end portion of the above tubular body with the tip portion thereof, into the aorta through the femoral artery and causing the first balloon to indwell in the aorta at a predetermined site, the step of causing a second balloon catheter having a second inflatable balloon at the tip of a flexible tubular body and a second hollow tubular part connecting the rear end portion of the above tubular body with the tip portion thereof, to indwell in the vena cava at a predetermined site, the step of blocking the blood flow at a lower limb side arterial site lower than the above predetermined site of the aorta, the step of blocking the blood flow at a lower limb side venous site lower than the above predetermined site of the cava, the step of inflating the first balloon to thereby form an intraarterial closed region between the above predetermined site of the aorta and the above lower limb side arterial site, the step of inflating the second balloon to thereby form an intravenous closed region between the above predetermined site of the cava and the above lower limb side venous site, the step of administering a body fluid containing a cancer therapeutic agent to the intraarterial closed region from the above first hollow tubular part, and the step of recovering a body fluid containing the cancer therapeutic agent from the above intravenous closed region through the second hollow tubular part, and the above cancer therapeutic agent is at least one agent chosen from the group of an anticancer agent, a radioisotope, a gene for gene therapy, a DNA molecule for gene therapy, RNA molecule for gene therapy and a cell for gene therapy.
An intrapelvic cancer therapeutic agent perfusion apparatus for administering a cancer therapeutic agent to and recovering the same from a cancer tissue site occurring within the pelvis which comprises a fluid feeding tube for intracorporeally feeding a cancer therapeutic agent-containing extracorporeal medical fluid and at least one of blood and a body fluid, a fluid discharge tube for discharging the intracorporeal cancer therapeutic agent-containing fluid and at least one of the blood and body fluid, a fluid feeding pump connected with the fluid feeding tube, a fluid discharge pump connected with the fluid discharge tube, a fluid feeding rate adjusting means connected with one of the fluid feeding tube and fluid feeding pump and capable of adjusting the rate of intracorporeal feeding of the cancer therapeutic agent-containing extracorporeal medical fluid and at least one of the blood and body fluid, and a fluid discharge rate adjusting means connected with one of the fluid discharge tube and fluid discharge pump and capable of adjusting the rate of extracorporeal discharging of the cancer therapeutic agent-containing intracorporeal medical fluid and at least one of the blood and body fluid in a manner such that the amount of the fluid extracorporeally discharged may become larger than the amount of the fluid fed.
Dependencies are inferred from the claim text.