Pyrimido[5,4-e] [1,2,4]triazine-5, 7-diamine compounds as protein tyrosine phosphatase inhibitors

A compound of the formula:

• 32
• wherein
• R1 and R2 are individually selected from the group consisting of hydrogen, or
• R1 and R2 together form a bond, —CH2—, —O—, —NH— or —N—R3,
• R3 is lower alkyl or —CH2—Ar, and
• Ar is selected from the group consisting of unsubstituted phenyl;
• unsubstituted naphthyl;
• phenyl mono- or bi-substituted with lower alkyl, lower alkoxy, aryl, cycloalkyl, lower alkyl-aryl, lower alkoxy-aryl, lower alkyl-cycloalkyl, lower alkoxy-cycloalkyl, halo, cyano or trifluoromethyl;
• and naphthyl mono- or bi-substituted with lower alkyl, lower alkoxy, aryl, cycloalkyl, lower alkyl-aryl, lower alkoxy-aryl, lower alkyl-cycloalkyl, lower alkoxy-cylcoalkyl or halo;
• or pharmaceutically acceptable salts thereof.