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US 2003/0153748 A1Published application
Cephalosporin intermediates
AssigneeSandoz Ltd.
InventorsPeter Kremminger, Johannes Ludescher, Siegfried Wolf
Life of this patent
Estimating the term…
Abstract
A process and intermediates in the production of cefotiam (hexetil).
Claims10
A process for the production of cefotiam of formula
- 6
- comprising
- (i) acylating a compound of formula
- 7
- with a compound of formula
- 8
- in an activated form;
- to obtain a compound of formula
- 9
- and
- (ii) deformylating a compound of formula I to obtain a compound of formula III:
8 more elements
A process for the production of cefotiam of formula
- 10
- comprising deformylating a compound of formula
- 11
- and isolating a compound of formula III.
1 more element
A compound of formula
- 12
A isolated compound of formula
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- in free form or in the form of a salt.
(6R,7R)-[1-(cyclohexyloxycarbonyloxy)ethyl]-7-[2-(2-formylamino-1,3-thiazol-4-yl)acetamido]-3-[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.
Dependencies are inferred from the claim text.