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US 2003/0153744 A1Published application
Anti-viral 7-deaza L-nucleosides
AssigneeMicrologix Biotech Inc.
InventorsKhalid Mekouar, Robert Deziel, Samir Mounir, Radhakrishnan P. Iyer
Life of this patent
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Abstract
The present invention comprises 7-deaza L-nucleosides having unexpectedly high inhibitory activity against the hepatitis B virus. The invention further comprises pharmaceutical compositions comprising such compounds as well as methods of treating mammals, particularly humans, infected with HBV and other viral infections.
Claims7
A compound of formula (I):
- 5
- and pharmaceutically acceptable salts thereof, wherein
- a) R1 is H, C1-C6-alkyl, —Cl, —OH, C1-C4-alkoxy, —NH2, or —NHZR5;
- b) R2 and R3 independently are —H, C1-C6-alkyl, methyl, C2-C6-alkenyl, C2-C6 alkynyl, —Cl, —I, —Br, —F, or heterocyclyl;
- or R2 and R3 together with the carbons to which they are attached form a 5 membered ring;
- c) R4 is —NHZR5 or —N(R5)2, wherein Z is —CO— or —SO2— and R5 is C1-C6-alkyl, C5-C6-cycloalkyl, or aryl;
- or R4 is H, —OH, C1-C6-alkyl, C1-C6-alkenyl, C1-C4-alkoxy, or —NH2;
- d) X and Y are independently —N— or —CH—;
- and
- e) R6, R7, R8, and R9 are independently —H, —OH, C1-C6-alkyl, —NH2, —NHZR5, —F, —Cl, or —Br.
7 more elements
Dependencies are inferred from the claim text.