Human ABH
AssigneeHuman Genome Sciences, Inc.
InventorsYing-Fei Wei, Granger G. Sutton III
Life of this patent
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Abstract
A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.
Claims20
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide as set forth in SEQ ID NO:2;
- (b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and
- (c) a polynucleotide fragment of the polynucleotide of (a) or (b).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide which encodes a mature polypeptide encoded by the DNA contained in ATCC Deposit No. 75855;
- (b) a polynucleotide which encodes a polypeptide expressed by the DNA contained in ATCC Deposit No. 75855;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
A polypeptide selected from the group consisting of:
- (a) a polypeptide having the deduced amino acid sequence of SEQ ID NO:2 and fragments, analogs and derivatives thereof;
- (b) a polypeptide comprising amino acid 1 to amino acid 262 of SEQ ID NO:2;
- and
- (c) a polypeptide encoded by the cDNA of ATCC Deposit No. 75855 and fragments, analogs and derivatives of said polypeptide.
Dependencies are inferred from the claim text.