Novel polypepetide
AssigneeAstellas Pharma Inc.
InventorKunio Yasunaga
Life of this patent
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Abstract
A novel polypeptide, a polynucleotide encoding this polypeptide, a expression vector comprising this polynucleotide, a cell transfected with the expression vector, and a pharmaceutical composition for promoting type II collagen production, a pharmaceutical composition for promoting aggrecan production, and a pharmaceutical composition for treating and/or preventing osteoarthritis comprising the above polypeptide as an active ingredient are disclosed. The polypeptide exhibits an activity of promoting type II collagen production and/or an activity of promoting aggrecan production.
Claims16
(1) A polypeptide having an amino acid sequence consisting of the 23rd to 388th amino acids in an amino acid sequence of Seq Id No:
- 2, or
- (2) a polypeptide having an amino acid sequence in which one or plural amino acids are deleted, substituted, and/or added at one or plural positions in an amino acid sequence consisting of the 23rd to 388th amino acids in an amino acid sequence of Seq Id No:
- 2, and exhibiting an activity of promoting type II collagen production and/or an activity of promoting aggrecan production;
A polypeptide comprising an amino acid sequence consisting of the 23rd to 388th amino acids in an amino acid sequence of SEQ ID NO:
- 2, and exhibiting an activity of promoting type II collagen production and/or an activity of promoting aggrecan production.
A polypeptide having an amino acid sequence having a 90% or more homology with an amino acid sequence consisting of the 23rd to 388th amino acids in an amino acid sequence of SEQ ID NO:
- 2 or with an amino acid sequence of SEQ ID NO:
- 2, and exhibiting an activity of promoting type II collagen production and/or an activity of promoting aggrecan production.
A polypeptide having an amino acid sequence consisting of the 1st to 388th or 23rd to 388th amino acids in an amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.