Aldose reductase inhibitors and pharmaceutical compositions
AssigneeO.N.C.E.-(Organizacion Nacional De Cicgos)
InventorsTeresa Garcia de Quesada Fort, Jesus A De La Fuente Blanco, Ma Jesus Martin Lopez, Isabel Reymundo Cuesta
Life of this patent
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Abstract
1 Medicaments for treating diabetic complications contain a compound of formula (A), wherein at least one Y or one Y′ is OH, and the remainder are selected from H, Hal, OH, OMe and NO2; X is O, S, keto or a direct link.
Claims8
1) The use for the manufacture of a medicament for the treatment and/or prevention of diabetic complications of a compound represented by the following general formula (A)
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- wherein at least one of Y or Y′ is OH and the others Y and Y′ are independently selected from the group consisting of hydrogen, halogen, hydroxy, methoxy, and nitro;
- X is selected from the group consisting of O, S, and ketone, or both subtituted benzyl groups are directly linked as a subtituted biphenyl compound.
- In addition, these aldose reductase inhibitors can form salts with a pharmaceutically acceptable cation, all such salts are within the scope of this invention:
- In addition, some of the compounds of this invention can form hydrates or solvates and they are also within the scope of the invention.
2) The use of a compound represented by the general formula (A) for the manufacture of a medicament for the treatment and/or prevention of diabetic neuropathy, diabetic cataract and retinopathy, diabetic corneal keratopathy, diabetic nephropathy, diabetic dermopathy and other diabetic microangiopathies.
3) A compound according to the general formula (A) where X═O, Y2═Y2′═OH, Y6═Y6′═H, and Y3═Y3′═Y4═Y4′═Y5═Y5′═Br.
4) A compound according to the general formula (A) where X═O, Y2═Y2′═Y4OH, Y6═Y6′═H, and Y3═Y3′═Y4′═Y5═Y5′═Br.
5) A compound according to the general formula (A), where X═O, Y2═Y2′═OH, Y6═Y6′═H, and Y3═Y3′═Y4═Y4′═Y5═Y5′═Cl).
6) A compound according to the general formula (A), where X═CO, Y2═Y2′═OH, Y4═Y4′═Y6═Y6′═H, and Y3═Y3′═Y5═Y5′═Br.
7) A compound according to the general formula (A), where X=nothing, Y4═Y4′═OH, and Y2═Y2′═Y3═Y3′═Y5═Y5′═Y6═Y6′═Br.
8) A compound according to the general formula (A), where X=nothing, Y4═Y4′═OH, and Y2═Y2′═Y3═Y3′═Y5═Y5′═Y6═Y6′═Cl.
Dependencies are inferred from the claim text.