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US 2003/0153610 A1Published application
Substituted oxazolidinones and their in the field of blood coagulation
AssigneeBayer HealthCare LLC
InventorsAlexander Straub, Thomas Lampe, Jens Pohlmann, Susanne Rohrig, Elisabeth Perzborn, Karl-Heinz Schlemmer, Joseph Pernerstorfer
Life of this patent
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Abstract
The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) 1 processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
Claims15
Compounds of the general formula (I)
- 174
- in which:
- R1 represents optionally benzo-fused thiophene (thienyl) which may optionally be mono- or polysubstituted;
- R2 represents any organic radical;
- R3, R4, R5, R6, R7 and R8 are identical or different and each represents hydrogen or represents (C1-C6)-alkyl
- and their pharmaceutically acceptable salts, hydrates and prodrugs,
- except for compounds of the general formula (I) in which the radical R1 is an unsubstituted 2-thiophene radical and the radical R2 is simultaneously a mono- or polysubstituted phenyl radical and the radicals R3, R4, R5, R6, R7 and R8 are each simultaneously hydrogen.
4 more elements
Use of compounds of the general formula (I)
- 183
- in which:
- R1 represents optionally benzo-fused thiophene (thienyl) which may optionally be mono- or polysubstituted;
- R2 represents any organic radical;
- R3, R4, R5, R6, R7 and R8 are identical or different and each represents hydrogen or represents (C1-C6)-alkyl
- and their pharmaceutically acceptable salts, hydrates and prodrugs,
- for preparing medicaments or pharmaceutical compositions for the prophylaxis and/or treatment of thromboembolic disorders, in particular myocardial infarct, angina pectoris (including unstable angina), reocclusions and restenoses after angioplasty or aorto-coronary bypass, stroke, transitory ischaemic attacks, peripheral arterial occlusive diseases, pulmonary embolisms or deep venous thromboses.
4 more elements
Dependencies are inferred from the claim text.