Thiazolidinedione derivatives for the treatment of diabetes and other diseases

A compound of the formula:

• 60
• wherein:
• R1 and R2 together with the aromatic ring bonded thereto comprise a cycloalkyl or cycloalkenyl ring having 3 to 8 carbon atoms that optionally comprises 1 or 2 heteroatoms selected from O, S, NH or N-alkyl, and wherein the cycloalkyl or cycloalkenyl ring is optionally further substituted with one or more groups independently selected from halogen, alkyl, hydroxyl, alkoxy, substituted alkoxy, carboxy, carboalkoxy, alkylcarboxamide, substituted alkylcarboxamide, dialkylcarboxamide, substituted dialkylcarboxamide, amino, mono-substituted amino or di-substituted amino;
• R3 and R4 are independently or together hydrogen, halogen, alkyl, substituted alkyl, haloalkyl, alkoxy, substituted alkoxy, amino, mono-substituted amino, di-substituted amino or haloalkoxy;
• Ar is Formula (VI), (VII) or (VIII):
• 61
• wherein:
• R8 is alkyl, substituted alkyl, alkenyl, haloalkyl, hydroxy, acyloxy, halogen, alkoxy, substituted alkoxy, amino, mono-substituted amino, di-substituted amino, alkylamide or haloalkoxy;
• and
• R9 and R10 are independently or together hydrogen, halogen, alkyl, substituted alkyl, haloalkyl, alkenyl, substituted alkenyl, alkoxy, hydroxyl, amino, mono-substituted amino, di-substituted amino, alkylamide or haloalkoxy;
• R5 is hydrogen, or alkyl;
• — represents a bond present or absent;
• and
• W, X, Y and Z together form a 2,4-thiazolidinedione or a 2-thioxo-4-thiazolidinedione;
• or a pharmaceutically acceptable salt thereof.