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US 2003/0153600 A1Published application
5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl in pure crystalline form and process for synthesis
AssigneeMerck & Co., Inc.
InventorsLouis S. Crocker, Ian W. Davies, Richard G. Osifchin, Andrew Kotliar
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Abstract
This invention encompasses the Form V polymorph of Compound A of structural formula: 1 which is useful in the treatment of cyclooxygenase-2 mediated diseases. The invention encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising the Form V polymorph of Compound A. The invention also encompasses a process for synthesizing the Form V polymorph of Compound A.
Claims18
A polymorphic form of the compound of formula A:
- 6
- which is designated Form V.
A process for making a Form V polymorph of structural formula A:
- 7
- comprising:
- combining polymorph I, II, III or IV of Compound A with isopropyl acetate;
- heating to an elevated temperature less than about 75° C.;
- and
- cooling to a low temperature to produce the Form V polymorph.
3 more elements
Dependencies are inferred from the claim text.