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US 2003/0153586 A1Published application
7-oxo-pyridopyrimidines (I)
AssigneeSyntex (U.S.A.) Inc.
InventorsJian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
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Abstract
The present invention provides compounds of the formula: 1 wherein R1, R2, R3 and Ar1 are those defined herein, and methods for preparation and uses thereof.
Claims30
A compound of the formula:
- 310
- or salts thereof, wherein:
- R1 is hydrogen or alkyl;
- R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-alkyl, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl (where n is 1 or 2) or —SO2Ar2;
- R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, —NRa—C(═O)—Rb (where Ra is hydrogen or alkyl and Rb is heterocyclyl or heteroalkyl), alkyl, cycloalkyl, phthalimidoalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -alkylene-C(O)—R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) or acyl;
- and
- each of Ar1 and Ar2 is independently aryl.
4 more elements
A composition comprising:
- (a) an excipient;
- and
- (b) a compound of the formula:
- 312
- or pharmaceutically acceptable salts thereof, wherein:
- R2 is hydrogen or alkyl;
- R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-alkyl, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl (where n is 1 or 2) or SO2Ar2;
- R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, —NRa—C(═O)—Rb (where Ra is hydrogen or alkyl and Rb is heterocyclyl or heteroalkyl), alkyl, cycloalkyl, phthalimidoalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -alkylene-C(O)—R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) or acyl;
- and
- each of Ar1 and Ar2 is independently aryl.
7 more elements
Dependencies are inferred from the claim text.