CCR-3 receptor antagonists (I)

A compound of Formula (I):

• 57
• wherein:
• R1 is (C1-C2)alkylene;
• R2 is optionally substituted phenyl;
• R3 is hydrogen, alkyl, acyl, aryl, or arylalkyl;
• ring A is a cycloalkyl, heterocyclyl, or optionally substituted phenyl;
• D is N or C—Rb;
• L is —C(═O)—, —C(═S)—, —SO2—, —C(═O)N(Ra)—, —C(═S) N(Ra)—, —SO2 N(Ra)—, —C(═O)O—, —C(═S)O—, —S(═O)2O—;
• R4 is alkyl, cycloalkyl, alkenyl, alkynyl, heteroalkyl or acylalkyl;
• Ra is hydrogen, alkyl, acyl, aryl, arylalkyl, alkoxycarbonyl, or benzyloxycarbonyl;
• and
• Rb is hydrogen or alkyl;
• and prodrugs, individual isomers, racemic and non-racemic mixtures of isomers, and pharmaceutically acceptable salts and solvates thereof.