Compounds and methods for the treatment of pain
AssigneeAstraZeneca AB
InventorsMegan Murphy, Rebecca Ann Urbanek, Wenhua Xiao, Gary Banks Steelman, Dean Gordon Brown, Thomas Michael Bare
Life of this patent
Estimating the term…
Abstract
Compounds according to structural diagram I are disclosed; 1 wherein R1, A and D are as defined in the specification. Also disclosed are methods for treating pain comprising administration of a pain-ameliorating effective amount of a compound in accord with structural diagram I and pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram I.
Claims10
Any compound according to structural diagram I;
- 6
- wherein:
- R1 is halo;
- A is (CH2)n where n is a value selected from 1, 2, 3 and 4;
- D is a five-membered heteroaryl moiety or a benz-derivative thereof, said heteroaryl moiety having one or two heteroatoms selected from oxygen, nitrogen and sulfur and having one or two substituents thereon,
- said substituents being selected from C1-4alkyl, phenyl, halo-substituted phenyl, halo, carboxy and C1-4alkoxycarbonyl,
- or tautomers or pharmaceutically-acceptable salts thereof.
A method for treating a subject suffering from pain comprising administering a pain-ameliorating effective amount of a compound according to structural diagram I
- 8
- wherein:
- R1 is halo;
- A is (CH2)n where n is a value selected from 1, 2, 3 and 4;
- D is a five-membered heteroaryl moiety or a benz-derivative thereof, said heteroaryl moiety having one or two heteroatoms selected from oxygen, nitrogen and sulfur and having one or two substituents thereon,
- said substituents being selected from C1-4alkyl, phenyl, halo-substituted phenyl, halo, carboxy and C1-4alkoxycarbonyl,
- or tautomers or pharmaceutically-acceptable salts thereof.
A pharmaceutical composition comprising a pain-ameliorating effective amount of a compound according to structural diagram I together with a pharmaceutically-acceptable excipient or diluent;
- 9
- wherein:
- R1 is halo;
- A is (CH2)n where n is a value selected from 1, 2, 3 and 4;
- D is a five-membered heteroaryl moiety or a benz-derivative thereof, said heteroaryl moiety having one or two heteroatoms selected from oxygen, nitrogen and sulfur and having one or two substituents thereon,
- said substituents being selected from C1-4alkyl, phenyl, halo-substituted phenyl, halo, carboxy and C1-4alkoxycarbonyl,
- or tautomers or pharmaceutically-acceptable salts thereof.
Dependencies are inferred from the claim text.