Method and composition for the treatment of pain
OwnerDean Gordon Brown, Thomas Michael Bare +5inventors
InventorsDean Gordon Brown, Thomas Michael Bare, Megan Murphy, Rebecca Ann Urbanek, Wenhua Xiao, Marie Frances McLaren, Carey Lynn Horchler
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Abstract
A method for the treatment of pain is disclosed comprising administration of a pain-ameliorating effective amount of any compound according to structural diagram I; 1 wherein R1, A and D are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram I.
Claims5
A method for treating a subject suffering from pain comprising administering a pain-ameliorating effective amount of any compound according to structural diagram I;
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- wherein:
- R1 is halo;
- A is CH(R2)(CH2)n where n has a value selected from 0, 1 or 2;
- R2 is selected from C1-6alkyl, and
- D is selected from a five- or six-membered heteroaryl moiety or a benz- derivative thereof having 1, 2 or 3 ring atoms selected from nitrogen oxygen or sulfur, where D is unsubstituted or substituted with one, two or three moieties selected from C1-3alkoxy, halo and cyano.
A pharmaceutical composition comprising a pain-ameliorating effective amount of a compound according to structural diagram I together with a pharmaceutically-acceptable excipient or diluent;
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- wherein:
- R1 is halo;
- A is CH(R2)(CH2)n where n has a value selected from 0, 1 or 2;
- R2 is selected from C1-6alkyl, and
- D is selected from a five- or six-membered heteroaryl moiety or a benz- derivative thereof having 1, 2 or 3 ring atoms selected from nitrogen oxygen or sulfur, where D is unsubstituted or substituted with one, two or three moieties selected from C1-3alkoxy, halo and cyano.
Dependencies are inferred from the claim text.