4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy
AssigneeMerckle GmbH
InventorsHans-Guenter Striegel, Stefan Laufer, Karola Tollmann, Susanne Tries
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Abstract
The present invention relates to 4-pyridyl- und 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy, of the formula 1 1 in which the variables have the meanings indicated in the description. The compounds according to the invention have immunomodulating and/or cytokine release-inhibiting action and are therefore utilizable for the treatment of disorders which are connected with a disturbance of the immune system.
Claims8
A 4-pyridyl- or 2,4-pyrimidinyl-substituted pyrrole derivative and its use in pharmacy, of the formula
- 31
- in which
- one of the radicals R1, R2 and R3 is 4-pyridyl, 2,4-pyrimidyl or 3-amino-2,4-pyrimidyl, which is optionally substituted by one or two C1-C4-alkyl groups or halogen atoms,
- the second of the radicals R1, R2 and R3 is phenyl or thienyl, which is optionally substituted by one or two C1-C4-alkyl groups or halogen atoms, and
- the third of the radicals R1, R2 and R3 is H, CO2H, CO2C1-C6-alkyl, CH2OH or C1-C6-alkyl,
- R4 and R5 independently of one another are H or C1-C6-alkyl;
- X is CH2, s or O and
- n is 1 or 2,
- and the optical isomers, physiologically tolerable salts and physiologically easily hydrolyzable esters thereof.
A compound of the formula I as claimed in one of the preceding claims, where the third of the radicals R1, R2 and R3 is CO2H.
Dependencies are inferred from the claim text.