Novel compounds

A compound of general formula

• 4
• wherein:
• m is 0, 1, 2 or 3;
• each R1 independently represents halogen, cyano, nitro, carboxyl, hydroxyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, C1-C6 haloalkyl, to C1-C6 haloalkoxy, -NR9R10, C3-C6 cycloalkylamino, C1-C6 alkylthio, C1-C6 alkylcarbonyl, C1-C6 alkylcarbonylamino, sulphonamido, C1-C6 alkylsulphonyl, -C(O)NR11 R12 , -NR13C(O)-(NH)pR14, phenyl, or C1-C6 alkyl optionally substituted by carboxyl or C1-C6 alkoxycarbonyl;
• p is 0 or 1;
• X represents an oxygen atom or a CH2, OCH2, CH2O, CH2NH, NH, carbonyl or sulphonyl group and Y represents a nitrogen atom or a CH or C(OH) group, provided that when X represents an oxygen atom or a CH2O, CH2NH or NH group, then Y represents a CH group;
• Z1 represents a bond or a group (CH2)q where q is 1 or 2;
• Z2 represents a bond or a group CH2, with the proviso that Z1 and Z2 do not both simultaneously represent a bond;
• Q represents an oxygen or sulphur atom or a group CH2 or NH;
• R2 represents a group
• 5
• n is 0, 1 or 2;
• each R3 independently represents a C1-C6 alkyl, C1-C6 alkoxycarbonyl, -CH2OH or carboxyl group;
• R4, R5, R6 and R7 each independently represent a hydrogen atom or a C1-C6 alkyl group, or R4, R5, R6 and R7 together represent a C1-C4 alkylene chain linking the two carbon atoms to which they are attached to form a 4- to 7-membered saturated carbocycle, or R5, R6 and R7 each represent a hydrogen atom and R4 and R8 together with the carbon atoms to which they are attached form a 5- to 6-membered saturated carbocycle;
• R5 represents a hydrogen atom, a C1-C6 alkyl group or is linked to R4 as defined above;
• R9 and R10 each independently represent a hydrogen atom or a C1-C6 alkyl group, or R9 and R10 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocycle;
• R11 and R12 each independently represent a hydrogen atom or a C1-C6 alkyl group optionally substituted by C1-C6 alkoxycarbonyl;
• R13 represents a hydrogen atom or a C1-C6 alkyl group;
• R14 represents a hydrogen atom, or a C1-C6 alkyl group optionally substituted by carboxyl, C1-C6 alkoxy or C1-C6 alkoxycarbonyl;
• R15 represents a group C2-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C5-C6 cycloalkenyl, adamantyl, phenyl or a saturated or unsaturated 5- to 10-membered heterocyclic ring system comprising at least one heteroatom selected from nitrogen, oxygen and sulphur, wherein each group may be optionally substituted by one or more substituents independently selected from nitro, hydroxyl, oxo, halogen, carboxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylcarbonyl, Cl-C6 alkoxycarbonyl, phenyl and -NHC(O)-R17, with the proviso that R15 does not represent an unsubstituted 1-pyrrolidinyl, an unsubstituted 1-piperidinyl or an unsubstituted 1-hexamethyleneiminyl group;
• t is 0, 1, 2 or 3;
• each R6 independently represents halogen, cyano, nitro, carboxyl, hydroxyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, -NR18R19, C3-C6 cycloalkylamino, C1-C6 alkylthio, C1-C6 alkylcarbonyl, C1-C6 alkylcarbonylamino, sulphonamido (-SO2NH2), C1-C6 alkylsulphonyl, -C(O)NR20R21, -NR22C(o)(NH) R 3, phenyl, or C1-C6 alkyl optionally substituted by carboxyl or C1-C6 alkoxycarbonyl;
• R17 represents a C1-C6 alkyl, amino or phenyl group;
• R18 and R19 each independently represent a hydrogen atom or a C1-C6 alkyl group, or R18 and R19 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocycle;
• R20 and R21 each independently represent-a hydrogen atom or a C1-C6 alkyl group optionally substituted by C1-C6 alkoxycarbonyl;
• v is 0 or 1;
• R22 represents a hydrogen atom or a C1-C6 alkyl group;
• and
• R23 represents a hydrogen atom, or a C1-C6 alkyl group optionally substituted by carboxyl, C1-C6 alkoxy or C1-C6 alkoxycarbonyl;
• or a pharmaceutically acceptable salt or solvate thereof.