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US 2003/0153554 A1Published application
Short-acting sedative hypnotic agents for anesthesia and sedation
AssigneeTheravance, Inc.
InventorsThomas E. Jenkins, Sabine Axt, Jennifer Bolton
Life of this patent
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Abstract
The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
Claims26
A compound of formula (I):
- 12
- wherein
- R1 is selected from the group consisting of (C2-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl(C1-C6)alkyl, phenyl, and benzyl;
- R2 and R3 are each independently selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, and (C2-C6)alkynyl, or R2 and R3, together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 5 to 7 atoms, and
- R4 is selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, and (C2-C6)alkynyl;
- provided that the sum of the number of carbon atoms in R1, R2, R3, and R4 is greater than 7.
3 more elements
The compound having the chemical name [4-[(N,N-diethylcarbamoyl)methoxy]-3-ethoxyphenyl]acetic acid propyl ester.
A compound of formula (II):
- 13
- wherein
- R1 is selected from the group consisting of (C2-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl(C1-C6)alkyl, phenyl, and benzyl;
- R4 is selected from the group consisting of (C1-C6)alkyl, (C2-C6)alkenyl, and (C2-C6)alkynyl;
- and
- R5 is hydrogen or hydroxyl.
3 more elements
Dependencies are inferred from the claim text.