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US 2003/0153552 A1Published application
Method of treating chemical dependency in mammals and a composition therefor
OwnerDeborah C. Mash, Juan Sanchez-Ramos +1inventors
InventorsDeborah C. Mash, Juan Sanchez-Ramos, William Lee Hearn
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Abstract
An essentially pure noribogaine compound having the formula: 1 wherein R is hydrogen or a hydrolyzable group of the formula: 2 wherein X is an unsubstituted C1-C12 group or a C1-C12 group substituted by lower alkyl or lower alkoxy groups, wherein the noribogaine compound having the hydrolyzable group hydrolyzes in vivo to form 12-hydroxy ibogamine.
Claims18
An essentially pure noribogaine compound having the formula:
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- wherein R is hydrogen or a hydrolyzable group of the formula:
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- wherein X is an unsubstituted C1-C12 group or a C1-C12 group substituted by lower alkyl or lower alkoxy groups, wherein said noribogaine compound having said hydrolyzable group hydrolyses in vivo to form 12-hydroxy ibogamine.
1 more element
A pharmaceutical composition for treating chemical dependency in a mammal, which comprises:
- a) an amount of one or more noribogaine compounds having the formula:
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- wherein R is hydrogen or a hydrolyzable group of the formula:
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- wherein X is an unsubstituted C1-C12 group or a C1-C12 group substituted by lower alkyl or lower alkoxy groups, effective to reduce craving for a chemical substance in said mammal, thereby treating the chemical dependency, and
- b) a pharmaceutically acceptable excipient.
3 more elements
Dependencies are inferred from the claim text.