Method to potentiate the therapeutic efficacy of taxane and derivatives thereof
OwnerMarius Monshouwer, Robert Ings +1inventors
InventorsMarius Monshouwer, Robert Ings, Maurizio Rocchetti
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Abstract
The use of estramustine phosphate and its metabolites estramusfine and estromustine allow to potentiate the therapeutic efficacy of taxanes by both improving their pharmacokinetic and pharmacodynamidc profile through the inhibition of (CYP)2C8 and (CYP)3A4 enzymes, both responsible for the metabolism of the taxanes; formulations of estramustine phosphate and metabolites, combinations of these latter with taxanes and therapeutic methods of treatment comprising them as a combined therapy are also disclosed.
Claims48
Use of estramustine phosphate or a metabolite thereof in the preparation of a medicament which potentiates the therapeutic efficacy of a taxane.
An agent for use in potentiating the therapeutic efficacy of a taxane comprising estramustine phosphate or a metabolite thereof.
A combination which potentiates the therapeutic efficacy of a taxane which comprises estramustine phosphate or a metabolite thereof for administration on the day of, or within 3 days of, administration of the said taxane.
A product comprising estramustine phosphate or a metabolite thereof and a taxane as a combined preparation for simultaneous, separate or sequential use in anticancer therapy.
A method of treating a patient in need of taxane therapy, which method comprises administering estramustine phosphate or a metabolite thereof and a taxane to the said patient.
A method of potentiating the therapeutic efficacy of a taxane, which method comprises administering to a patient in need thereof a taxane and estramustine phosphate or a metabolite thereof.
Use of estramustine phosphate or a metabolite thereof in the preparation of a medicament which modifies the systemic exposure or the pharmacokinetic profile of a taxane.
Dependencies are inferred from the claim text.