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US 2003/0153534 A1Published application
Phosphonate nucleotide compound
AssigneeMitsubishi Pharma Corporation
InventorsMasaru Ubasawa, Kouichi Sekiya
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Abstract
The 2-amino-6-arylthiopurinephosphonate of the present invention has no toxicity such as bone marrow cell growth inhibition and mutagenicity, and has a high anti-viral activity, oral absorbency and safety. Furthermore, the compound of the present invention can be produced in a short process. Therefore, the present invention can provide an excellent anti-viral agent which can efficiently be produced.
Claims13
A phosphonate nucleotide compound represented by the following formula (I) or a salt thereof, or a hydrate or solvate thereof:
- 7
- wherein,
- R1 is a hydroxyl group;
- each of R2 and R3 is independently a hydrogen atom, a C1-C22 alkyl group, an acyloxymethyl group, an acylthioethyl group, or an ethyl group substituted by one or more halogen atoms;
- R4 is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 hydroxyalkyl group, or a C1-C4 alkyl group substituted by one or more halogen atoms;
- and X is CH or a nitrogen atom.
3 more elements
Dependencies are inferred from the claim text.