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US 2003/0153533 A1Published application
Novel phospholipid derivatives
AssigneeZentaris AG
InventorsGerhard Nossner, Bernhard Kutscher, Jurgen Engel, Wolfgang Schumacher, Jurij Stekar, Peter Hilgard
Life of this patent
Estimating the term…
Abstract
Novel phospholipid derivatives of the General Formula I: 1 processes for their preparation and their use as medications are described.
Claims20
Compounds of general formula I:
- 7
- in which
- R is a linear or branched alkyl radical having 10 to 24 carbon atoms, which can also contain one to three double or triple bonds, R1 and R2 independently of one another are hydrogen or in each case a linear, branched or cyclic saturated or unsaturated alkyl radical having 1 to 6 carbon atoms, which can also contain a Cl, OH or NH2 group, it also being possible for two of these radicals to be bonded together to form a ring,
- A is a single bond or one of the groups of the formulae
- —CH2—CH2—CH2—O— (II)—CH2—CH2—O— (III) 8
- the groups (II) to (VI) being orientated in such a way that the oxygen atom is bonded to the phosphorus atom of compound (I), X is an oxygen or sulphur atom or NH when A is a single bond, or an oxygen or sulphur atom when A is one of the groups (II) to (IV),
- y is equal to 0 or a natural number between 1 and 3, and
- m and n independently of one another are 0 or natural numbers, with the proviso that m+n=2 to 8.
5 more elements
A compound selected from the group consisting of octadecyl 1,1-dimethylpiperidinio-4-yl phosphate and octadecyl 1,1-dimethylhexahydroazepinio-4-yl phosphate.
Dependencies are inferred from the claim text.