Modified polysaccharides exhibiting altered biological recognition
OwnerBo E. Hedlund, Thomas P. Weber +3inventors
InventorsBo E. Hedlund, Thomas P. Weber, Paul R. Dragsten, Gregory J. Hanson, Philip E. Hallaway
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Abstract
The invention relates to polysaccharides, polysaccharide conjugates and complexes with altered biological properties, and methods to produce these polysaccharides, polysaccharide conjugates and complexes.
Claims6
A pharmaceutical composition comprising a partially oxidized and reduced water-soluble polysaccharide complex, wherein the polysaccharide is unmodified starch, and a pharmaceutically acceptable vehicle, wherein about 20% to 80% of vicinal hydroxyl groups of the polysaccharide have been oxidized.
A method of increasing the vascular half life of a starch-iron complex comprising the steps of:
- a. oxidizing about 20% to about 90% of the vicinal hydroxyl groups of unmodified starch;
- b. reducing the oxidized starch;
- c. forming a starch-iron complex using the oxidized and reduced starch;
- and
- d. administering the oxidized and reduced starch-iron complex into the circulation of a mammal.
Dependencies are inferred from the claim text.