Control of membrane traffic
OwnerThierry Galli, Daniel Louvard +1inventors
InventorsThierry Galli, Daniel Louvard, Sonia Martinez
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Abstract
The present invention relates to the control of membrane traffic inside cells, such as those involving fusion events and in particular those involving exocytic events. It more particularly relates to N-terminal fragments of TeNT-insentive VAMP, and to TeNT-insentive VAMP deleted from such fragments, and to the biological applications of such products, notably for controlling TeNT-resistant pathways such as neurite outgrowth and cell motility.
Claims31
Isolated polpeptide, the sequence of which is selected from the group consisting of a sequence corresponding to SEQ ID NO2, a sequence corresponding to SEQ ID NO20, the sequences corresponding to any conservative treatment of SEQ ID NO2, the sequences corresponding to any conservative fragment of SEQ ID NO20, the sequences corresponding to any conservative variant of SEQ ID NO2, the sequences corresponding to any conservative variant of SEQ ID NO20.
Isolated polypeptide, the sequence of which is selected from the group consisting of SEQ ID NO4, the sequences corresponding to any conservative variant of SEQ ID NO4, and the sequences corresponding to any conservative fragment of SEQ ID NO4.
Isolated polynucleotide, the sequence of which is selected from the group consisting or a sequence corresponding to SEQ ID NO1, a sequence corresponding to SEQ ID NO19, the sequences corresponding to any conservative fragment of SEQ ID NO1, by the sequences corresponding to any conservative variant of SEQ ID NO1, the sequences corresponding to any conservative fragment of SEQ ID NO19, the sequences corresponding to any conservative variant of SEQ ID NO19.
Isolated polynucleotide, the sequence of which is selected from the group consisting of a sequence corresponding to SEQ ID NO3, the sequences corresponding to any conservative fragment of SEQ ID NO3, the sequences corresponding to any conservative variant of SEQ ID NO3.
Pair of oligonucleotides of which respective sequences correspond to SEQ ID NO11 and SEQ ID NO12.
Pair of oligonucleotides of which respective sequences correspond to SEQ ID NO15 and SEQ ID NO16.
Dependencies are inferred from the claim text.