Methods of increasing endogenous erythropoietin (EPO)
OwnerStephen J. Klaus, Al Y. Lin +6inventors
InventorsStephen J. Klaus, Al Y. Lin, Thomas B. Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Michael P. Arend, Lee A. Flippin, Alex Melekhov
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
Claims46
A method for increasing endogenous erythropoietin (EPO) in a subject, the method comprising stabilizing the alpha subunit of hypoxia inducible factor (HIFα).
A method for increasing endogenous EPO in a subject, the method comprising inhibiting hydroxylation of HIFα.
A method for increasing endogenous EPO in a subject, the method comprising inhibiting 2-oxoglutarate dioxygenase enzyme activity.
A method for increasing endogenous EPO levels in a subject, the method comprising inhibiting HIF prolyl hydroxylase enzyme activity.
A method for treating, preventing, or pretreating an EPO-associated disorder in a subject, the method comprising increasing endogenous EPO.
A method for treating, preventing, or pretreating an EPO-associated disorder in a subject, the method comprising stabilizing HIFα.
A method for treating, preventing, or pretreating an EPO-associated disorder in a subject, the method comprising inhibiting hydroxylation of HIFα.
A method for treating, preventing, or pretreating an EPO-associated disorder in a subject, the method comprising inhibiting 2-oxoglutarate dioxygenase enzyme activity.
A method for treating, preventing, or pretreating an EPO-associated disorder in a subject, the method comprising inhibiting HIF prolyl hydroxylase enzyme activity.
A method for treating, preventing, or pretreating anemia in a subject, the method comprising increasing endogenous EPO.
A method for treating, preventing, or pretreating a neurological disorder in a subject, the method comprising increasing endogenous EPO.
A method for enhancing oxygen consumption in a subject, the method comprising increasing endogenous EPO.
A method for identifying a compound that increases endogenous EPO, the method comprising:
- (a) administering a compound to a subject;
- (b) measuring EPO in the subject or in a sample from the subject;
- and
- (c) comparing the EPO in the subject or in the sample to a standard, wherein an increase in the EPO in the subject or in the sample relative to the standard is indicative of a compound that increases endogenous EPO.
Dependencies are inferred from the claim text.