Human tumor necrosis factor receptor-like proteins TR11, TR11SV1, and TR11SV2

An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence at least 95% identical to a sequence selected from the group consisting of:

• (a) a nucleotide sequence encoding the TR11 polypeptide having the complete amino acid sequence shown in FIGS. 1A and 1B (amino acid residues −25 to 209 in SEQ ID NO:2);
• (b) a nucleotide sequence encoding the TR11SV1 polypeptide having the complete amino acid sequence shown in FIGS. 2A and 2B (amino acid residues 1 to 241 in SEQ ID NO:4);
• (c) a nucleotide sequence encoding the TR11SV2 polypeptide having the complete amino acid sequence shown in FIGS. 3A and 3B (amino acid residues −19 to 221 in SEQ ID NO:6);
• (d) a nucleotide encoding the complete amino sequence shown in FIGS. 1A and 1B but lacking the N-terminal methionine (i.e., amino acids −24 to 209 in SEQ ID NO:2);
• (e) a nucleotide encoding the complete amino sequence shown in FIGS. 2A and 2B but lacking the N-terminal methionine (i.e., amino acids 2 to 240 in SEQ ID NO:4);
• (f) a nucleotide encoding the complete amino sequence shown in FIGS. 3A and 3B but lacking the N-terminal methionine (i.e., amino acids −18 to 221 in SEQ ID NO:6);
• (g) a nucleotide sequence encoding the predicted mature TR11 receptor comprising the amino acid sequence at positions from 26 to 234 in FIGS. 1A and 1B (amino acid residues 1 to 209 in SEQ ID NO:2);
• (h) a nucleotide sequence encoding the predicted mature TR11SV2 receptor comprising the amino acid sequence at positions from 20 to 240 in FIGS. 3A and 3B (amino acid residues 1 to 221 in SEQ ID NO:6);
• (i) a nucleotide sequence encoding the TR11 polypeptide having the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit Number 209341;
• (j) a nucleotide sequence encoding the TR11SV1 polypeptide having the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit Number 209342;
• (k) a nucleotide sequence encoding the TR11SV2 polypeptide having the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit Number 209343;
• (l) a nucleotide sequence encoding the mature TR11 receptor having the amino acid sequences encoded by the cDNA clone contained in ATCC Deposit Number 209341;
• (m) a nucleotide sequence encoding the mature TR11SV1 receptor having the amino acid sequences encoded by the cDNA clone contained in ATCC Deposit Number 209342;
• (n) a nucleotide sequence encoding the mature TR11SV2 receptor having the amino acid sequences encoded by the cDNA clone contained in ATCC Deposit Number 209343;
• (o) a nucleotide sequence encoding the TR11 receptor extracellular domain;
• (p) a nucleotide sequence encoding the TR11SV1 receptor extracellular domain;
• (q) a nucleotide sequence encoding the TR11SV2 receptor extracellular domain;
• (r) a nucleotide sequence encoding the TR11 receptor transmembrane domain;
• (s) a nucleotide sequence encoding the TR11SV1 receptor transmembrane domain,
• (t) a nucleotide sequence encoding the TR11SV2 receptor transmembrane domain;
• (u) a nucleotide sequence encoding the TR11 receptor intracellular domain;
• (v) a nucleotide sequence encoding the TR11SV1 receptor intracellular domain;
• (w) a nucleotide sequence encoding the TR11SV2 receptor intracellular domain;
• (x) a nucleotide sequence encoding the TR11 receptor extracellular and intracellular domains with all or part of the transmembrane domain deleted;
• (y) a nucleotide sequence encoding the TR11SV1 receptor extracellular and intracellular domains with all or part of the transmembrane domain deleted;
• (z) a nucleotide sequence encoding the TR11SV2 receptor extracellular and intracellular domains with all or part of the transmembrane domain deleted;
• and
• (aa) a nucleotide sequence complementary to any of the nucleotide sequences in (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (p), (q), (r), (s), (t), (u), (v), (w), (x), (y) or (z).