Mucosal repair by TFF dimer peptides
OwnerLars Thim, Steen Seier Poulseninventors
Life of this patent
Estimating the term…
Abstract
The present invention relates to the use of trefoil factor 1 (TFF1) and trefoil factor 3 (TFF3) dimers and a pharmaceutical composition comprising TFF dimers for increasing the viscosity of mucin in mucus layers and the repair of damaged mucus layers in the gastrointestinal tract (mouth, oesophagus, stomach, small and large intestine, colon) the respiratory passages, the eye, the urinary system (including the bladder) and the cervis uteri.
Claims52
A pharmaceutical composition for increasing the viscosity of mucus layers in mammals, the composition comprising a TFF dimer peptide or a pharmaceutically acceptable salt thereof.
Use of a TFF dimer peptide for the preparation of a medicament for increasing the viscosity of mucus layers in mammals.
A method for increasing viscosity of mucus layers in a subject, said method comprising administering to the subject a composition comprising
- a) a pharmaceutically acceptable carrier or diluent,
- b) a therapheutically effective amount of a trefoil factor (TFF) dimer peptide, and optionally
- c) a mucin glycoprotein preparation.
Dependencies are inferred from the claim text.