Insulin conjugates and methods of use thereof
AssigneeDiatos, S.A.
InventorJean-Leon Tchelingerian
Life of this patent
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Abstract
The invention relates generally to chimeric peptides and compositions that facilitate the transport of insulin across biological membranes, methods for preparing the chimeric peptides, and a method for treating a subject suffering from diabetes.
Claims42
A chimeric peptide comprising a first domain and a second domain, wherein the first domain comprises a translocation sequence which facilitates active transport across a biological membrane and the second domain comprises at least a portion of an insulin polypeptide.
A peptide comprising a first domain, a second domain, and a third domain;
- the first domain and the second domain comprising an amino acid sequence selected from the group consisting of:
- (a) (XBBBXXBX)n;
- (b) (XBBXBX)n;
- (c) (BBXmBBXo)n;
- (d) (XBBXXBX)n;
- and
- (e) (BXBB)n,
- (f) an antibody fragment,
- wherein
- B is a basic amino acid;
- X is a non-basic amino acid;
- each m is independently an integer from zero to five;
- each n is independently an integer between one and ten;
- and
- each o is independently an integer between zero to five, wherein the first domain is different from the second domain and wherein the third domain comprises at least a portion of an insulin polypeptide, wherein the chimeric peptide translocates a biological membrane.
A chimeric peptide comprising a first domain and a second domain, wherein the first domain comprises the amino acid sequence of SEQ ID NO:30 and the second domain comprises at least a portion of an insulin polypeptide.
A chimeric peptide comprising a first domain and a second domain, wherein the first domain comprises the amino acid sequence of SEQ ID NO:35 and the second domain comprises at least a portion of an insulin polypeptide.
A chimeric peptide comprising:
- (a) at least a portion of a CDR3 region of an anti-DNA antibody;
- (b) at least a portion of CDR2 region of an anti-DNA antibody;
- and
- (c) at least a portion of an insulin polypeptide;
- wherein the peptide tranlocates a biological membrane.
Dependencies are inferred from the claim text.