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US 2003/0153065 A1Published application
Composition and method for maintaining non-enveloped viral vectors
AssigneeGenVec, Inc.
InventorsImre Kovesdi, Stephen C. Ransom
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Abstract
The invention provides a composition and a method for preserving a non-enveloped viral vector. The composition comprises (a) trehalose, (b) a divalent metal salt, a cationic polymer, or a combination thereof, (c) a multiplicity of non-enveloped viral vector particles, and (d) a liquid carrier. Non-enveloped virus particles are stable in the composition in a liquid form, at elevated temperatures, for a sustained period of time.
Claims26
A composition for maintaining a non-enveloped viral vector comprising:
- (a) about 1-25% (wt./vol.) trehalose,
- (b) about 0.05-2 mM of a divalent metal salt, a cationic polymer, or a combination thereof,
- (c) a multiplicity of non-enveloped viral vector particles, and
- (d) a liquid carrier.
1 more element
Dependencies are inferred from the claim text.