Disintegrin homologue, MAHBP
AssigneeZymoGenetics, Inc.
InventorsPaul O. Sheppard, Nand Baindur, Theresa A. Deisher, Paul D. Bishop, David W. Taft
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Abstract
The present invention relates to polynucleotide and polypeptide molecules for MAHBP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are believed to be cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAHBP polypeptides.
Claims31
An isolated polypeptide molecule the amino acid sequence as shown in SEQ ID NO:10 from residue 670 to residue 687.
An isolate polypeptide molecule wherein the polypeptide molecule is selected from the group consisting of:
- a) a polypeptide molecule comprising the amino acid sequence as shown in SEQ ID NO:10 from residue 465 to 669;
- and
- b) a polypeptide molecule comprising the amino acid sequence as shown in SEQ ID NO:10 from residue 1 to 163.
An isolated polypeptide molecule selected from the group consisting of:
- a) a polypeptide molecule comprising residues 670 to 687 of SEQ ID NO:2;
- b) a polypeptide molecule comprising residues 688 to 709 of SEQ ID NO:2;
- and
- c) a polypeptide molecule comprising residues 670 to 709 of SEQ ID NO:2.
An isolated polynucleotide molecule encoding a polypeptide, wherein the polypeptide comprises amino acids 1 to 709 of SEQ ID NO:10.
An isolated polynucleotide molecule consisting of nucleotides 1 to nucleotides 2159 of SEQ ID NO:9.
An isolated polynucleotide molecule consisting of nucleotides 492 to 2159 of SEQ ID NO:9.
An isolated polynucleotide molecule consisting of nucleotides 1149 to 2159 of SEQ ID NO:9.
An isolated polynucleotide molecule encoding a fusion protein having a first segment and a second segment, wherein the first segment comprises a first polynucleotide encoding a polypeptide having a protease domain and the second segment comprises a second polynucleotide encoding a polypeptide that has a contiguous sequence of 14 amino acids between residues 383 and 464 of SEQ ID NO:10, and wherein the first segment is positioned amino-terminally to the second segment.
Dependencies are inferred from the claim text.