Method for influencing kinase activity with AG879
OwnerHong He, Hiroshi Marutainventors
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Abstract
The invention relates to the use of AG879 and its derivatives as kinase inhibitors. The molecules can be used, per se, as inhibitors, or they can be used in connection with screening assays to identify modifiers of kinase activity.
Claims27
A method for determining if a substance is a modifier of a kinase molecule which is also modified by AG879, comprising admixing said substance and said kinase, measuring a property of said kinase, and comparing said property to said property when said kinase is admixed with AG879, to determine if said substance is a modifier of said kinase.
A method for inhibiting a kinase selected from the group consisting of PAK1, FAK, and ETK, comprising contacting said kinase with AG879 or a derivative thereof, in an amount sufficient to inhibit said kinase.
Dependencies are inferred from the claim text.