US 2003/0152989 A1 · Novel human integral membrane protein

Abstract

The present invention provides a novel human integral membrane (IMP-2) and polynucleotides which identify and encode IMP-2. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding IMP-2 and a method for producing IMP-2. The invention also provides for agonists, antibodies, or antagonists specifically binding IMP-2, and their use, in the prevention and treatment of diseases associated with expression of IMP-2. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding IMP-2 for the treatment of diseases associated with the expression of IMP-2. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding IMP-2.

Claims57

Dependent claims

An isolated polypeptide selected from the group consisting of:

a) a polypeptide comprising an amino acid sequence of SEQ ID NO:
1,
b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:
1,
c) a biologically active fragment of a polypeptide having an amino acid sequence of SEQ ID NO:
1, and
d) an immunogenic fragment of a polypeptide having an amino acid sequence of SEQ ID NO:
1.

5 more elements

Dependencies are inferred from the claim text.

Novel human integral membrane protein

Life of this patent

Novel human integral membrane protein

Life of this patent

Abstract

Claims57