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OwnerMorag A Grassie, Derek Gatherer +1inventors
InventorsMorag A Grassie, Derek Gatherer, Colin Andrew McLean Semple
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The present invention provides a full length cDNA sequence that codes for a G-protein coupled receptor, as well as the complete gene and the encoded protein. The present invention provides a recombinant cell line expressing these receptors at appropriate levels such that novel compounds active at these receptors may be identified for therapeutic use. The receptor sequence described in this invention is a member of a novel GPCR receptor sub-family which has no known endogenous ligand. This cDNA can be used to identify novel compounds active at the receptor for therapeutic intervention especially in the field of CNS disorders, more in particular for the treatment of bipolar affective disorder (BPAD). The nucleotide sequence of this gene could he used for diagnostic purposes in psychiatric patients and susceptible populations.
A substantially pure polynucleotide, encoding the amino acid sequence of SEQ ID NO:
A polypeptide according to SEQ ID NO:
Use of a polynucleotide hybridisable to the ORG3 gene in the in vitro diagnosis of a psychiatric disorder, wherein ORG3 gene is defined as a stretch of DNA hybridisable to the polynucleotide sequence according to SEQ ID NO:
Use of a polypeptide encoded by a polynucleotide comprising SEQ ID NO 2 or fragments thereof in the in vitro diagnosis of a psychiatric disorder.
A polynucleotide comprising SEQ ID NO 1 or fragments thereof for use as a medicament.
A polypeptide encoded by a polynucleotide comprising SEQ ID NO 2 or fragments thereof for use as a medicament
A polynucleotide comprising SEQ ID NO 2 or fragments thereof for use as a medicament for the treatment of a psychiatric disorder.
A polypeptide encoded by a polynucleotide comprising SEQ ID NO 2 or fragments thereof for use as a medicament for the treatment of a psychiatric disorder
Use of a polynucleotide comprising SEQ ID NO 2 or fragments thereof in the preparation of a medicament for the treatment of a psychiatric disorder
Use of a polypeptide encoded by a polynucleotide comprising SEQ ID NO 2 or fragments thereof in the preparation of a medicament for the treatment of a psychiatric disorder
Method for the detection of a mutation in the ORG3 gene in a given subject comprising the steps of
Dependencies are inferred from the claim text.