Methods for detection of promoter polymorphism in a UGT gene promoter

A method for detecting polymorphisms in the uridine diphosphate glucuronosyltransferase I (UGT1A1) gene promoter comprising determining the number of thymidine-adenine, (TA) repeats in said promoter, wherein the number of TA repeats correlates with expression of the gene.

A method for screening individuals for variation in glucuronidation activity comprising detecting polymorphisms in a uridine diphosphate glucuronosyltransferase (UGT) gene promoter comprising determining the number of thymidine-adenine (TA) repeats in said promoter, wherein the number of TA repeats correlates with expression of the gene.

A method for screening individuals for variation in glucuronidation activity comprising detecting polymorphisms in a uridine diphosphate glucuronosyltransferase I (UGT1A1) gene promoter, the method comprising determining the number of thymidine-adenine (TA) repeats in said promoter, wherein the number of TA repeats in said promoter correlates with expression of the UGT gene.

A method for optimizing drug dosages for a patient wherein said drugs are glucuronidated by a uridine diphosphate glucuronosyltransferase (UGT), said method comprising determining the number of thymidine-adenine (TA) repeats in a promoter of the UGT gene wherein the number of TA repeats correlates with expression of said UGT gene, and wherein the activity of said drug is effected by its level of glucuronidation.

A method for optimizing drug dosages wherein said drugs are glucuronidated by uridine diphosphate glucuronosyltransferase I, said method comprising determining the number of thymidine-adenine (TA) repeats in a promoter of the UGT1 gene wherein the number of TA repeats correlates with expression of said UGT gene, and wherein the activity of said drug is effected by its level of glucuronidation.

A method for predicting an individual's sensitivity to xenobiotics wherein said xenobiotics are glucuronidated by a uridine diphosphate glucuronosyltransferase gene product, said method comprising determining the number of thymidine-adenine (TA) repeats in a UGT gene promoter, wherein the number of TA repeats correlates with expression of said UGT gene and wherein the individual's sensitivity to said xenobiotics is effected by glucuronidation activity.

A method for predicting an individual's sensitivity to xenobiotics wherein said xenobiotics are glucuronidated by a uridine diphosphate glucuronosyltransferase I gene product, said method comprising determining the number of thymidine-adenine (TA) repeats in a UGT1 gene promoter, wherein the number of TA repeats correlates with expression of said UGT1 gene and wherein the individual's sensitivity to said xenobiotics is effected by glucuronidation activity.

A kit for detecting polymorphisms in a uridine diphosphate glucuronosyltransferase (UGT) gene promoter wherein the number of thymidine-adenine (TA) repeats in said UGT gene promoter correlates to expression of said UGT gene, the kit comprising primers for amplifying DNA comprising all or part of the UGT gene promoter to determine the number of TA repeats in said promoter.

A kit for detecting polymorphisms in a uridine diphosphate glucuronosyltransferase I (UGT1A1) gene promoter wherein the number of thymidine-adenine (TA) repeats in said UGT1 gene promoter correlates to expression of said UGT1 gene, the kit comprising primers for amplifying DNA comprising all or part of the UGT1 gene promoter to determine the number of TA repeats in said promoter.