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US 2003/0152965 A1Published application
HCV core protein sequences
AssigneeOrtho-Clinical Diagnostics, Inc.
InventorChander Bahl
Life of this patent
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Abstract
The present invention describes peptides and recombinant proteins containing Hepatitis C virus core protein sequence in which one or more of the amino acids have been modified or deleted to remove the ability of these proteins to bind to specific anti-HCV murine monoclonal antibodies. The deletions and modifications are designed as to maintain the ability of this protein to be used in immunoassays used for the detection of anti-HCV antibodies in individuals infected with HCV.
Claims6
A kit for the detection of HCV comprising
- A) a solid phase coated with modified HCV core protein, HCV non-core protein, and at least one anti-HCV core monoclonal antibody, and
- B) a labeled anti-HCV core monoclonal antibody, wherein the modified core protein of part A) has been modified by removing the binding sites of the anti-core monoclonal antibodies of part A) and part B).
Dependencies are inferred from the claim text.