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US 2003/0152951 A1Published application
IL-4 receptor sequence variation associated with type 1 diabetes
OwnerDaniel B. Mirel, Henry A. Erlich +3inventors
InventorsDaniel B. Mirel, Henry A. Erlich, Teodorica L. Bugawan, Janelle A. Noble, Ana Maria Valdez
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Abstract
The present invention provides methods and reagents for determining sequence variants present at the IL4R locus, which facilitates identifying individuals at risk for type 1 diabetes.
Claims21
A method for determining an individual's risk for type 1 diabetes comprising, detecting the presence of an IDDM-associated IL4R allele in a nucleic acid sample of the individual, wherein the presence of said allele indicates the individual's risk for type 1 diabetes.
A kit for determining an individual's risk for type 1 diabetes comprising,
- (a) one or more sequence-specific oligonucleotides each individually comprising a sequence that is fully complementary to a sequence in an IDDM-associated IL4R allele, wherein said sequence comprises one or more polymorphisms associated with said allele;
- and
- (b) instructions to use the kit to determine the individual's risk for type 1 diabetes.
Dependencies are inferred from the claim text.