Methods for detecting and treating the early onset of aging-related conditions
OwnerDavid C. Crossman, Gordon W. Duff +3inventors
InventorsDavid C. Crossman, Gordon W. Duff, Sheila E. Francis, Katherine Stephenson, Kenneth S. Kornman
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Abstract
Certain aspects of the invention relate to methods for determining a subject's susceptibility to the early onset or progression of aging-related conditions. In certain aspects the invention relates to accessing the genotype of a subject with respect to an allele of IL-1 pattern 1, pattern 2 and/or pattern 3. In other aspects, the invention relates to methods for selecting a therapeutic regimen, identifying age-related biomarkers, monitoring the progress of age-related conditions and identifying therapeutics for delaying or diminishing the onset of aging-related conditions.
Claims36
A method for determining a subject's susceptibility to the early onset or progression of an aging-related condition, comprising accessing the subject's genotype with respect to at least one allele of an IL-1 pattern 1, pattern 2 and/or pattern 3, wherein the presence or absence of the at least one allele of an IL-1 pattern 1, pattern 2 and/or pattern 3 provides information about the subject's susceptibility to an early onset or progression of an aging-related condition.
A method for selecting an appropriate therapeutic regimen or lifestyle recommendation for a subject, comprising accessing the subject's genotype with respect to at least one allele of an IL-1 pattern 1 or pattern 2 or pattern 3, wherein the presence or absence of the at least one allele of an IL-1 pattern 1, pattern 2 and/or pattern 3 provides information about the subject's susceptibility to an early onset or progression of an aging-related condition, and allowing the selection of a therapeutic regimen or lifestyle recommendation that is suitable to the subject's susceptibility to an early onset of an aging-related condition.
A method for predicting the potential for cell division of a subject's endothelial cells, comprising accessing the subject's genotype with respect to at least one allele of an IL-1 pattern 1, pattern 2 and/or pattern 3, wherein the presence or absence of the at least one allele of an IL-1 pattern 1, pattern 2 and/or pattern 3 provides information about the potential for cell division of the subject's endothelial cells.
A method for identifying a biomarker useful for determining an aging-related phenotype comprising,
- (a) measuring a biomarker in at least one subject having an EOA-associated allele to obtain a first measured value;
- and
- (b) measuring said biomarker in at least one subject having a non-EOA-associated genotype to obtain a second measured value,
- wherein if said first measured value differs from said second measured value, said first measured value is an aging-related phenotype and said biomarker is a biomarker that is useful for determining an aging-related phenotype.
A method for screening test substances to identify a test substance that is likely to prevent or diminish the early onset or progression of an aging-related condition, the method comprising:
- (a) observing a biomarker in a cell containing DNA comprised of at least one allele of pattern 1, pattern 2 and/or pattern 3 to obtain a first measured value of the biomarker;
- (b) contacting the cell with a test substance;
- and
- (c) observing the biomarker in the cell to obtain a second measured value of the biomarker, wherein a change in the measured value of the biomarker from a senescence-related phenotype to a non-senescence-related phenotype identifies a test substance that is likely to prevent or diminish the early onset or progression of aging-related diseases and conditions.
A method for screening genes to identify a gene that is likely to prevent or diminish the early onset or progression of an aging-related condition in a subject, said method comprising:
- (a) contacting a cell containing DNA comprised of at least one allele of pattern 1, pattern 2 and/or pattern 3 with a test gene under conditions causing the test gene to enter one or more of the cells;
- and
- (b) observing at least one biomarker in the subject, wherein a change in a biomarker from a senescence-related phenotype to a non-senescence-related phenotype identifies a test gene that is likely to prevent or diminish the early onset of aging-related diseases and conditions.
A cellular composition comprising cultured endothelial cells heterozygous for the IL-1 RN (VNTR) allele 2.
A cellular composition comprising cultured endothelial cells homozygous for the IL-1 RN (VNTR) allele 2.
Dependencies are inferred from the claim text.