Human monoclonal antibody against coreceptors for human immunodeficiency virus
AssigneeGenetastix Corporation
InventorsShaobing Hua, Michelle H. Pauling, Li Zhu
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Abstract
Compositions are provided that comprise antibody against coreceptors for human immunodeficiency virus such as CCR5 and CXCR4. In particular, monoclonal human antibodies against human CCR5 are provided that bind to CCR5 with high affinity and are capable of inhibiting HIV infection at low concentrations. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection, for screening drugs, and for diagnosing diseases or conditions associated with interactions with HIV coreceptors.
Claims35
An antibody that binds to loop 6 of human CCR5 and inhibits infection of immunodeficiency virus of human cells.
A recombinant expression vector encoding a polypeptide selected from the group consisting of SEQ ID NOs:
- 36-41.
A recombinant cell expressing a polypeptide selected from the group consisting of SEQ ID NOs:
- 36-41.
An antibody than binds to the N-terminus of human CCR5 and comprises a heavy chain variable region identified by SEQ ID NO:
- 34.
Dependencies are inferred from the claim text.