Extended release particle dispersion
AssigneeLaboratorios Farmaceuticos Rovi, S.A.
InventorRoland Bodmeier
Life of this patent
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Abstract
The invention relates to extended release compositions that can be advantageously used as drug products, plant protection agents, in foods or other products. The invention especially relates to liquid compositions in which extended release particles are dispersed. The compositions according to this invention are available in the form of single-dose or multi-dose compositions and as such are produced from liquid preproducts. The invention further relates to kits and methods for producing the compositions and to the preproducts thereof.
Claims49
A ready-to-use single- or multi-dose dispersion composition comprising solidified particles that provide an extended release of one or more active compounds;
- wherein
- a) the extended release particles are formed by mixing at least two liquid preproducts, which are present in portions suitable for the preparation of the single- or multi-dose composition;
- b) the first liquid preproduct comprises a carrier material that solidifies to form the extended release particles and, optionally, a biocompatible solvent or solvent mixture;
- c) the second liquid preproduct comprises a biocompatible liquid within which the first liquid preproduct forms the extended release particles;
- and
- d) one or more active compounds are independently included in the first liquid preproduct and/or the second liquid preproduct.
A method for the preparation of a ready-to-use single- or multi-dose -dispersion of extended release particles that provide an extended release of one or more active compounds, the method comprising the step of:
- a) providing at least two liquid preproducts;
- b) providing at least one active compound in dissolved, emulsified and/or suspended form in at least one of the at least two liquid preproducts;
- c) mixing at least two of the liquid preproducts, which are present in portions suitable for the preparation of the single- or multi-dose dispersion, to form a dispersion of a first liquid preproduct within a second liquid preproduct;
- wherein the first liquid preproduct comprises a carrier material that solidifies to form the extended release particles and, optionally, a biocompatible solvent or solvent mixture;
- and the second liquid preproduct comprises a biocompatible liquid within which the first liquid preproduct forms the extended release particles.
A kit for the preparation of a ready-to-use single- or multi-dose dispersion of extended release particles, the kit comprising at least two liquid preproducts each of which is present in a portion for the preparation of a single- or multi-dose composition;
- wherein
- a) at least two of the preproducts are liquid and wherein the extended release particles can be formed by mixing the preproducts;
- b) a first liquid preproduct comprises a carrier material that solidifies to form the extended release particles and, optionally, a biocompatible solvent or solvent mixture;
- c) a second liquid preproduct comprises a biocompatible liquid within which the first liquid preproduct forms the extended release particles;
- and
- d) one or more active compounds are independently included in the first liquid preproduct and/or the second liquid preproduct.
Dependencies are inferred from the claim text.