New pharmaceutical compositions
AssigneeNovartis AG
InventorsSteffen Lang, Kurt Liechti
Life of this patent
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Abstract
Spontaneously dispersible pharmaceutical compositions comprising a piperidine, e.g. 1-acylpiperidine Substance P Antagonist and its use in the treatment of CNS disorders, e.g. depression and social phobia, and respiratory diseases, e.g. asthma and chronic bronchitis.
Claims13
A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist.
A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist and a carrier medium comprising
- 1) a hydrophilic component and
- 2) a surfactant.
A composition as claimed in any preceding claim comprising a lipophilic component.
A pharmaceutical composition comprising (2R,4S)-N-(1-(3,5-bis(trifluoromethyl)-benzoyl)-2-(4-chlorobenzyl)-4-piperidinyl)-quinoline-4-carboxamide as active agent and a carrier medium comprising
- 1) a hydrophilic phase,
- 2) a lipophilic phase, and
- 3) a surfactant.
A composition as claimed in any preceding claim in the form of a microemulsion preconcentrate.
A composition as claimed in any preceding claim wherein the hydrophilic component comprises triethyl citrate or propylene glycol, wherein the surfactant comprises a reaction product of a natural or hydrogenated castor oil with ethylene oxide or a polyoxyethylene fatty acid ester, and wherein the lipophilic component comprises a transesterified ethoxylated vegetable oil, a C8 to C10 fatty acid mono-, di and/or tri-glyceride, a medium chain fatty acid triglyceride or a refined glycerol-transesterified corn oil.
A spontaneously dispersible pharmaceutical composition comprising about 0.05 to about 20% by weight of (2R,4S)-N-(1-(3,5-bis(trifluoromethyl)-benzoyl)-2-(4-chlorobenzyl)-4-piperidinyl)-quinoline-4-carboxamide, about 5 to about 50% by weight of a hydrophilic component, about 5 to about 80% by weight of a surfactant, and optionally about 5 to about 85% by weight of a lipophilic component, all weights based on the total composition.
A composition as claimed in any preceding claim in the form of a microemulsion.
A composition according to any preceding claim in unit dosage form.
A method of treatment of a subject suffering from a disorder treatable with aa piperidine substance P antagonist comprising administering a therapeutically effective amount of a pharmaceutical composition as claimed in any preceding claim to a subject in need of such treatment.
Dependencies are inferred from the claim text.