Tablet formulations comprising valsartan
OwnerSabina Maria Ganter, Robert Frank Wagnerinventors
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Abstract
The invention relates to solid oral dosage forms comprising pharmacologically effective amounts of valsartan or a pharmaceutically acceptable salt thereof or hydrate thereof. The compositions are at least 1.2 times more bioavailable than conventional valsartan capsule.
Claims12
An oral solid pharmaceutical composition comprising pharmacologically effective amounts of valsartan or a pharmaceutically acceptable salt thereof or hydrate thereof and at least one pharmaceutically acceptable excipient and which is, on average, at least 1.2 times more bioavailable than a valsartan capsule.
An oral solid pharmaceutical composition comprising pharmacologically effective amounts of valsartan or a pharmaceutically acceptable salt thereof or hydrate thereof and at least one pharmaceutically acceptable excipient and having an AUC higher than 4.5 h.mg/l at same conditions as a 40 mg capsule has an AUC of 3.9 h.mg/l.
An oral solid pharmaceutical composition comprising pharmacologically effective amounts of valsartan or a pharmaceutically acceptable salt thereof or hydrate thereof and at least one pharmaceutically acceptable excipient and having an AUC higher than 30 h.mg/l at same conditions as a 320 mg capsule has an AUC of 29.4 h.mg/l.
An oral solid pharmaceutical composition comprising pharmacologically effective amounts of valsartan or a pharmaceutically acceptable salt thereof or hydrate thereof and at least one pharmaceutically acceptable excipient and having a Cmax of about at least 0.77 mg/l when administered as a dose of 40 mg in a single dose human bioavailability study.
An oral solid pharmaceutical composition comprising pharmacologically effective amounts of valsartan or a pharmaceutically acceptable salt thereof or hydrate thereof and at least one pharmaceutically acceptable excipient and having a Cmax of about at least 4.75 mg/l when administered as a dose of 320 mg in a single dose human bioavailability study.
An oral solid pharmaceutical composition of valsartan or a pharmaceutically acceptable salt thereof or hydrate thereof comprising between 20% and 80% of a disintegrant based on the total weight of the composition.
Dependencies are inferred from the claim text.